Fully automated [18F]fluorocholine synthesis in the TracerLab MXFDG Coincidence synthesizer
| Autor: | Villeret Guillaume, Laurent Lemoucheux, David Kryza, Maria Azzurra Filannino, Vincent Luc Antoine Tadino |
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| Rok vydání: | 2008 |
| Předmět: |
Fluorine Radioisotopes
Cancer Research Radiochemistry Alkylation Chemistry Radiosynthesis Analytical chemistry Equipment Design Bridged Bicyclo Compounds Heterocyclic Methylation Coincidence Choline Bridged Bicyclo Compounds Fully automated Fluorodeoxyglucose F18 Molecular Medicine Radiology Nuclear Medicine and imaging Radiopharmaceuticals 18F-fluorocholine |
| Zdroj: | Nuclear Medicine and Biology. 35:255-260 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/j.nucmedbio.2007.11.008 |
| Popis: | Introduction We developed a new fully automated method for the radiosynthesis of [ 18 F]fluorocholine by modifying the commercial 2-[ 18 F]fluoro-2- d -deoxy-glucose ([ 18 F]FDG) synthesizer module (GE TracerLab MX, formerly Coincidence). Methods [ 18 F]Flurocholine was synthesized by 18 F-fluoroalkylation of N , N -dimethylaminoethanol using [ 18 F]fluorobromomethane as fluoromethylating agent. [ 18 F]Fluorobromomethane was produced by reaction of dibromomethane with [ 18 F]fluoride, assisted by Kryptofix 2.2.2. Results After purification on solid-phase extraction cartridges, the [ 18 F]fluorocholine was obtained in 15–25% radiochemical yields (decay not corrected), with more than 99% radiochemical purity. Specific activity was more than 37 GBq/μmol. Synthesis time was less than 35 min. Conclusion This new automated synthesis technique provides high and reproducible yields that could be dedicated for routine use with the same [ 18 F]FDG disposable cassette system. |
| Databáze: | OpenAIRE |
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