Pharmacokinetic interaction of ibuprofen enantiomers in rabbits

Autor:	Wenhui Lin, Toru Hayakawa, Hitomi Yanaguimoto, Mamoru Kuzuba, Takako Obara, Nobuo Inotsume, Fude Cui, Guohua Ding
Rok vydání:	2004
Předmět:	Pharmacology Chromatography Chemistry organic chemicals Pharmaceutical Science Ibuprofen Stereoisomerism Excretion Pharmacokinetics Area Under Curve Injections Intravenous medicine Animals Distribution (pharmacology) Stereoselectivity Rabbits Enantiomer Pharmacokinetic interaction medicine.drug
Zdroj:	Journal of Pharmacy and Pharmacology. 56:317-321
ISSN:	2042-7158 0022-3573
DOI:	10.1211/0022357022845
Popis:	The potential interaction between two ibuprofen enantiomers was studied after intravenous administration of R-(–)-, S-(+)- and racemic ibuprofen to rabbits. The total body clearance values calculated by compartmental model analysis (0.65+0.21 for R-(–)-ibuprofen and 0.63+0.34 for S-(+)-ibuprofen) after intravenous administration of the racemate of ibuprofen were significantly smaller than those of individual enantiomers (0.95+0.23 for R-(–)-ibuprofen and 1.03+0.23 for S-(+)-ibuprofen), indicating that the enantiomer–enantiomer interaction results in a mutual inhibition. The enantiomeric interaction in the pharmacokinetic behaviour of ibuprofen after racemic administration is considered to be a result of an alteration in the metabolic or excretion phase (or both) rather than stereoselective protein binding in the systemic distribution.
Databáze:	OpenAIRE
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