Inhibitory Effect of Drugs With A Ketone Group on Reduction of Acetohexamide Catalyzed By Carbonyl Reductase From Rabbit Kidney
| Autor: | Yorishige Imamura, E Sugino, Toshihisa Koga, Toshiyuki Higuchi, Satoshi Hibino, Masaki Otagiri |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Ketone
Carbonyl Reductase Stereochemistry Levobunolol Suprofen Pharmacology Kidney Biochemistry Substrate Specificity Propanolamines Structure-Activity Relationship Acetohexamide medicine Animals Enzyme Inhibitors Befunolol chemistry.chemical_classification Fenbufen Molecular Structure Phenylpropionates Anti-Inflammatory Agents Non-Steroidal Daunorubicin Loxoprofen Ketones Butyrophenones Alcohol Oxidoreductases Kinetics chemistry Molecular Medicine Rabbits Oxidation-Reduction medicine.drug |
| Zdroj: | Journal of Enzyme Inhibition. 11:285-292 |
| ISSN: | 8755-5093 |
| DOI: | 10.3109/14756369709027657 |
| Popis: | The reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney was inhibited by befunolol, moperone, levobunolol, daunorubicin and loxoprofen, which have a ketone group within their chemical structures and are substrates for the enzyme. A significant correlation was observed between the common logarithm of Vmax/Km values of the enzyme for befunolol, moperone, levobunolol and daunorubicin and the percentage inhibition of the enzyme, confirming that these drugs are competitive substrates of the enzyme with respect to acetohexamide. However, the plot for loxoprofen, a nonsteroidal anti-inflammatory drug with a ketone group, was apparently distant from the regression line obtained. Although nonsteroidal anti-inflammatory drugs with a ketone group such as suprofen and fenbufen were not reduced by the enzyme, they strongly inhibited the reduction of acetohexamide catalyzed by the enzyme. |
| Databáze: | OpenAIRE |
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