Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population

Autor: Teresa García-Gasca, Miriam Aracely Anaya-Loyola, Ulisses Moreno-Celis, Ma de Lourdes Anzures-Cortes, Víctor Manuel Rodríguez-García, Adriana Aguilar-Galarza, María Luisa Maycotte-Cervantes, Lorenza Haddad-Talancón, Akram Sharim Méndez-Rangel
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Genetic Markers
Male
Adolescent
Fatty Acid Elongases
Single Nucleotide Polymorphisms
Physiology
Nutritional Status
030209 endocrinology & metabolism
Single-nucleotide polymorphism
lcsh:TX341-641
ELOVL
Polymorphism
Single Nucleotide
High cholesterol
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
Insulin resistance
Gene Frequency
Risk Factors
medicine
Humans
Genetic Predisposition to Disease
Mexico
Alleles
Genetic Association Studies
Genetic association
Nutrition and Dietetics
medicine.diagnostic_test
business.industry
biomarkers
medicine.disease
Obesity
030104 developmental biology
Metabolism
Homeostatic model assessment
Mexican population
Female
metabolic alterations
Lipid profile
business
Body mass index
lcsh:Nutrition. Foods and food supply
Food Science
Zdroj: Nutrients, Vol 12, Iss 3389, p 3389 (2020)
Nutrients
Volume 12
Issue 11
ISSN: 2072-6643
Popis: The elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work focused on the study of ELOVL polymorphs with clinical markers of non-communicable chronic diseases in the Mexican population. A sample of 1075 participants was obtained, who underwent clinical, biochemical, and nutritional evaluation, and a genetic evaluation of 91 genetic variants of ELOVL was considered (2&ndash
7). The results indicate a 33.16% prevalence of obesity by body mass index, 13.84% prevalence of insulin resistance by homeostatic model assessment (HOMA) index, 7.85% prevalence of high cholesterol, and 20.37% prevalence of hypercholesterolemia. The deprived alleles showed that there is no association between them and clinical disease risk markers, and the notable finding of the association studies is that the ELOVL2 variants are exclusive in men and ELVOL7 in women. There is also a strong association of ELOVL6 with various markers. The present study shows, for the first time, the association between the different ELOVLs and clinical markers of chronic non-communicable diseases.
Databáze: OpenAIRE
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