(p-Phenylazophenyl)-Isopropyloxycarbonyl, a New Protecting Group for Peptide Synthesis
| Autor: | Aung Tun‐Kyi, Robert Schwyzer |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Biphenyl
Phenylpropionates Stereochemistry Organic Chemistry Biochemistry Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Group (periodic table) Drug Discovery Peptide synthesis Indicators and Reagents Acid treatment Physical and Theoretical Chemistry Peptides Protecting group Azo Compounds |
| Zdroj: | Helvetica Chimica Acta. 59:1642-1646 |
| ISSN: | 1522-2675 0018-019X |
| Popis: | The preparation and properties of thirty two N(α)-[2-(p-phenylazophenyl)-isopropylcarbonyl]-amino-acids and derivatives are described. The new coloured protecting group (AZOC-) can be easily and selectively removed with mild acid treatment, much the same as the 2-(biphenyl)-isopropyloxycarbonyl (BPOC-)group. It is introduced via quite stable and yet reactive, crystalline intermediates, AZOC-OPh and AZOC-N3. |
| Databáze: | OpenAIRE |
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