Phylogenetic and Ontogenetic View of Erythroblastic Islands
| Autor: | Theodosia A. Kalfa, Katie M. Giger |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Erythroblasts
Ontogeny Enucleation lcsh:Medicine Rodentia Review Article Biology General Biochemistry Genetics and Molecular Biology Phylogenetics Erythroblast hemic and lymphatic diseases Cellular Microenvironment Animals Humans Macrophage Erythropoiesis Phylogeny Mammals General Immunology and Microbiology Phylogenetic tree Macrophages lcsh:R Reptiles hemic and immune systems General Medicine Cell biology Immunology circulatory and respiratory physiology |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2015/873628 |
| Popis: | Erythroblastic islands are a hallmark of mammalian erythropoiesis consisting of a central macrophage surrounded by and interacting closely with the maturing erythroblasts. The macrophages are thought to serve many functions such as supporting erythroblast proliferation, supplying iron for hemoglobin, promoting enucleation, and clearing the nuclear debris; moreover, inhibition of erythroblastic island formation is often detrimental to erythropoiesis. There is still much not understood about the role that macrophages and microenvironment play in erythropoiesis and insights may be gleaned from a comparative analysis with erythropoietic niches in nonmammalian vertebrates which, unlike mammals, have erythrocytes that retain their nucleus. The phylogenetic development of erythroblastic islands in mammals in which the erythrocytes are anucleate underlines the importance of the macrophage in erythroblast enucleation. |
| Databáze: | OpenAIRE |
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