Obesity and Vitamin D Deficiency: Trends to Promote a More Proatherogenic Cardiometabolic Risk Profile
| Autor: | Milena Mitrović, Aleksandar Kupusinac, Branka Kovačev Zavišić, Edita Stokic, Sanja Soskic, Esma R. Isenovic, Dragana Smiljenic, Dragana Tomic-Naglic |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty obesity Waist vitamin D deficiency 030209 endocrinology & metabolism Body fat percentage Body Mass Index 03 medical and health sciences 0302 clinical medicine Insulin resistance Risk Factors Internal medicine cardiometabolic risk medicine Vitamin D and neurology Prevalence Humans Insulin 030212 general & internal medicine Obesity Vitamin D Adiposity 2. Zero hunger Metabolic Syndrome business.industry Middle Aged medicine.disease Atherosclerosis Vitamin D Deficiency Lipids Endocrinology Cross-Sectional Studies Case-Control Studies Female Insulin Resistance Waist Circumference Cardiology and Cardiovascular Medicine business Body mass index Serbia Dyslipidemia Biomarkers |
| Zdroj: | Angiology |
| Popis: | Vitamin D deficiency is associated with cardiometabolic risk factors (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese patients (body mass index [BMI]: 43.5 ± 9.2 kg/m2) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25(OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D levels were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L; P < .001). There was a negative correlation between vitamin D level and anthropometric indicators of obesity: BMI ( r = −0.64; P < .001), waist circumference ( r = −0.59; P < .001), and body fat percentage ( r = −0.64; P < .001) as well as with fasting plasma insulin ( r = −0.35; P < .001) and homeostasis model assessment of insulin resistance ( r = −0.35; P < .001). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. |
| Databáze: | OpenAIRE |
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