Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand
| Autor: | Siriphan Gongwon, Sataporn Thitivichianlert, Cecilia M. Shikuma, Suchitra Sukwit, Thippawan Chuenchitra, Suwicha Chitpatima, Bruce Shiramizu, Pasiri Sithinamsuwan, Silvia Ratto-Kim, Robert Paris, Jerome H. Kim, Mark de Souza, Bing Sun, Hans Rempel, Victor Valcour, Sorachai Nitayaphan, Samart Nidhinandana, Kenneth C. Williams, Lynn Pulliam |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male AIDS Dementia Complex CD4 antigen Immunology Enzyme-Linked Immunosorbent Assay HIV Infections Biology In Vitro Techniques Monocytes Statistics Nonparametric Article Cohort Studies chemistry.chemical_compound medicine Immunology and Allergy Dementia Humans Monocyte Viral Load medicine.disease Thailand Virology Phenotype CD4 Lymphocyte Count medicine.anatomical_structure Neurology chemistry Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Cohort CD4 Antigens HIV-1 Female Neurology (clinical) Complication Viral load Cohort study |
| Zdroj: | Journal of neuroimmunology. 195(1-2) |
| ISSN: | 0165-5728 |
| Popis: | HIV Associated Dementia (HAD) is a complication of HIV infection in developed countries and is still poorly defined in resource-limited settings. In this study we investigated the expression of the monocyte phenotype CD14CD16HLADR and the inflammatory profiles in monocytes supernatants by surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry in a cohort of HAD and non-HAD Thai volunteers prior to the initiation of ARV. The CD14CD16HLADR phenotype was significantly increased in monocytes from HAD and non-HAD versus negative controls, but there was no difference in phenotype and in the secretion protein profiles between the two seropositive groups. In addition, monocytes supernatants from HAD and non-HAD did not induced apoptosis or cell death in brain aggregate culture. In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts. |
| Databáze: | OpenAIRE |
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