Epidemic myalgia associated with human parechovirus type 3 infection among adults occurs during an outbreak among children: Findings from Yamagata, Japan, in 2011
| Autor: | Tsutomu Itagaki, Fumio Katsushima, Sueshi Ito, Chieko Abiko, Katsumi Mizuta, Tatsuya Ikeda, Hikaru Nagasawa, Yukitoshi Shimizu, Yoko Aoki, Tadayuki Ahiko, Hirokazu Kimura, Masahiro Noda, Tatsushi Yamakawa, Yuriko Katsushima, Makoto Kuroda |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Serum myalgia medicine.medical_specialty Virus Cultivation Adolescent Upper respiratory infections Virus isolation Molecular Sequence Data Parechovirus Pleurodynia Epidemic Disease Outbreaks Feces Japan Virology Throat Internal medicine medicine Cluster Analysis Humans Child Phylogeny Molecular Epidemiology Picornaviridae Infections Reverse Transcriptase Polymerase Chain Reaction business.industry Human parechovirus Infant Newborn Infant Outbreak Sequence Analysis DNA Summer season Infectious Diseases medicine.anatomical_structure Child Preschool Pharynx RNA Viral Female medicine.symptom business |
| Zdroj: | Journal of Clinical Virology. 58:188-193 |
| ISSN: | 1386-6532 |
| Popis: | Background Based on our findings in Yamagata, Japan, in 2008, we reported that human parechovirus type 3 (HPeV3) could be associated with epidemic myalgia among adults, although HPeV3 is generally associated with infectious diseases in children. Objectives To clarify the relationship between community outbreaks among children and myalgia through the continued surveillance of HPeV3 infections. Study design In the summer season (June–August) of 2011, we collected 586 specimens from children with infectious diseases, and throat swabs, and stool and serum specimens from 5 patients with myalgia. We detected HPeV3 using virus isolation and reverse-transcription PCR, and carried out phylogenetic analysis. We also performed screening for HPeV3 using 309 stocked frozen specimens collected in 2008 for a comparison between 2008 and 2011 strains. Results We detected HPeV3 in 59 children and isolated HPeV3 from all myalgia patients. Phylogenetic analysis indicated that the HPeV3 strains circulating in 2008 and 2011 could be clearly distinguished, apart from two strains. Further, we detected HPeV3 strains with identical nucleotide sequences from children and adults in 2008 and 2011, respectively. Two children belonging to one myalgia patient had upper respiratory infections prior to the onset of their father's illness, and the HPeV3 isolates from these three patients had identical nucleotide sequences. Conclusions These findings suggest that HPeV3, circulating among children in the community, infects their household, including parents, a portion of whom may subsequently show symptoms of myalgia. Our observations in 2008 and 2011 strongly suggest that clinical consideration should be given to HPeV3 in children as well as in adults during summer seasons in which an HPeV3 outbreak occurs among the children in the community. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect