Mild Hypophosphatemia-Associated Conditions in Children: The Need for a Comprehensive Approach
| Autor: | Pablo Docio, Sandra Llorente-Pelayo, María Teresa García-Unzueta, Bernardo A. Lavin-Gómez, Nuria Puente, Fátima Mateos, Leyre Riancho-Zarrabeitia, Domingo Gonzalez-Lamuño, José A. Riancho |
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| Přispěvatelé: | Universidad de Cantabria |
| Rok vydání: | 2022 |
| Předmět: |
GH deficiency
Hypophosphatemia Organic Chemistry General Medicine Catalysis Computer Science Applications Inorganic Chemistry Short stature hypophosphatemia diabetes mellitus thyroid disorders short stature Diabetes mellitus Physical and Theoretical Chemistry Thyroid disorders Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences 2023, 24, 687 International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 687 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24010687 |
| Popis: | To better understand the causes of hypophosphatemia in children, we evaluated all serum phosphate tests performed in a tertiary hospital with unexpected but persistent temporary or isolated hypophosphatemia over an 18 year period. We collected 29,279 phosphate tests from 21,398 patients, of which 268 (1.2%) had at least one result showing hypophosphatemia. We found that endocrinopathies (n = 60), tumors (n = 10), and vitamin D deficiency (n = 3) were the medical conditions most commonly associated with mild hypophosphatemia, but in many patients the cause was unclear. Among patients with endocrinopathies, those with diabetes mellitus were found to have lower mean serum phosphate levels (mean 3.4 mg/dL) than those with short stature (3.7 mg/dL) or thyroid disorders (3.7 mg/dL). In addition, we found a correlation between glycemia and phosphatemia in patients with diabetes. However, despite the potential relevance of monitoring phosphate homeostasis and the underlying etiologic mechanisms, renal phosphate losses were estimated in less than 5% of patients with hypophosphatemia. In the pediatric age group, malignancies, hypovitaminosis D, and endocrine disorders, mostly diabetes, were the most common causes of hypophosphatemia. This real-world study also shows that hypophosphatemia is frequently neglected and inadequately evaluated by pediatricians, which emphasizes the need for more education and awareness about this condition to prevent its potentially deleterious consequences. Funding: Supported by an investigator-initiated study (MD0075) funded by Kyowa-Kirin to J.A.R. |
| Databáze: | OpenAIRE |
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