Induction of therapeutic hypothermia by pharmacological modulation of temperature-sensitive TRP channels: theoretical framework and practical considerations
| Autor: | Sean P. Marrelli, Viktor V. Feketa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
TRPA1
Transient Receptor Potential cation channel subfamily A member 1 Physiology core temperature TRPV4 Transient Receptor Potential cation channel subfamily V member 4 pharmacological hypothermia Review therapeutic hypothermia Core temperature Biology thermopharmacology ThermoTRPs Transient receptor potential channel thermosensitive ion channels TRPV3 Transient Receptor Potential cation channel subfamily V member 3 Physiology (medical) Pharmacological modulation physical cooling MPA medial preoptic area of hypothalamus Communication thermoregulation business.industry TRP Transient Receptor Potential TRPV2 Transient Receptor Potential cation channel subfamily V member 2 Risk analysis (engineering) DMH dorso-medial hypothalamus TRPM8 Transient Receptor Potential cation channel subfamily M member 8 Temperature sensitive rMR rostral medullary raphe region business body temperature TRPV1 Transient Receptor Potential cation channel subfamily V member 1 ThermoTRPs Thermosensitive Transient Receptor Potential cation channels |
| Zdroj: | Temperature: Multidisciplinary Biomedical Journal |
| ISSN: | 2332-8940 |
| Popis: | Therapeutic hypothermia has emerged as a remarkably effective method of neuroprotection from ischemia and is being increasingly used in clinics. Accordingly, it is also a subject of considerable attention from a basic scientific research perspective. One of the fundamental problems, with which current studies are concerned, is the optimal method of inducing hypothermia. This review seeks to provide a broad theoretical framework for approaching this problem, and to discuss how a novel promising strategy of pharmacological modulation of the thermosensitive ion channels fits into this framework. Various physical, anatomical, physiological and molecular aspects of thermoregulation, which provide the foundation for this text, have been comprehensively reviewed and will not be discussed exhaustively here. Instead, the first part of the current review, which may be helpful for a broader readership outside of thermoregulation research, will build on this existing knowledge to outline possible opportunities and research directions aimed at controlling body temperature. The second part, aimed at a more specialist audience, will highlight the conceptual advantages and practical limitations of novel molecular agents targeting thermosensitive Transient Receptor Potential (TRP) channels in achieving this goal. Two particularly promising members of this channel family, namely TRP melastatin 8 (TRPM8) and TRP vanilloid 1 (TRPV1), will be discussed in greater detail. |
| Databáze: | OpenAIRE |
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