High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia
| Autor: | Sebastian G. B. Amyes, Abdulla Al-Taher, Abdulrahman A. Alsultan, Benjamin A. Evans, Abdullah M. Al-Dughaym, Sahar I. Al-Thawadi, A. Hamouda, Elsayed A. Elsayed |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Acinetobacter baumannii Carbapenem Saudi Arabia Tigecycline Drug resistance Microbial Sensitivity Tests Microbiology beta-Lactamases Diabetes Complications Antibiotic resistance Bacterial Proteins Diabetes mellitus Drug Resistance Bacterial medicine polycyclic compounds Diabetes Mellitus Prevalence Humans In patient biology business.industry General Medicine biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification bacterial infections and mycoses Anti-Bacterial Agents Carbapenems Colistin bacteria business medicine.drug Acinetobacter Infections |
| Zdroj: | Journal of medical microbiology. 62(Pt 6) |
| ISSN: | 1473-5644 |
| Popis: | Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A bla VIM gene was detected in ~95 % of isolates; bla OXA-23 and bla OXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required. |
| Databáze: | OpenAIRE |
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