Quantitative analysis of choriocapillaris alterations in swept-source optical coherence tomography angiography in diabetic patients
| Autor: | Ronan Kermarrec, Laurent Kodjikian, Christine Vartin, Philippe Denis, Lucas Gervolino, Antoine Maignan, Claudine Chambard, Thibaud Mathis, Olivier Loria, Sarra Dimassi, Pierre Pradat |
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| Přispěvatelé: | Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Groupe Hospitalier Public du Sud de l'Oise [Creil] (GHPSO), Institut des Sciences et Techniques de la Réadaptation [Lyon] (ISTR), Université de Lyon-Université de Lyon, Laboratoire de cristallographie et sciences des matériaux (CRISMAT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Fundus Oculi [SPI.MAT]Engineering Sciences [physics]/Materials 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Diabetic retinopathy Ophthalmology Humans Medicine Prospective Studies Fluorescein Angiography Stage (cooking) Macular edema 030304 developmental biology 0303 health sciences Choroid business.industry Healthy subjects Retinal Vessels OCT angiography Choriocapillaris General Medicine Optical coherence tomography angiography Middle Aged medicine.disease eye diseases Flow voids 030221 ophthalmology & optometry Female sense organs business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | RETINA. The Journal of Retinal and Vitreous Diseases RETINA. The Journal of Retinal and Vitreous Diseases, 2021, 41 (9), pp.1809-1818. ⟨10.1097/IAE.0000000000003102⟩ RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2021, 41, pp.1809-1818. ⟨10.1097/IAE.0000000000003102⟩ |
| ISSN: | 0275-004X 1539-2864 |
| DOI: | 10.1097/IAE.0000000000003102⟩ |
| Popis: | PURPOSE To evaluate quantitative alterations of the choriocapillaris in swept-source optical coherence tomography angiography in diabetic patients. METHODS We included normal patients and diabetic patients with and without diabetic retinopathy (DR), excluding patients with macular edema. Angiograms in 3 × 3 mm were acquired with Plexelite 9000 swept-source optical coherence tomography angiography. Choroidal flow voids were analyzed after removal of projection artifacts. The main evaluation was the correlation between choroidal flow voids area (FVA-CC) and DR stage. RESULTS A total of 120 eyes of 72 patients were analyzed. There were 17 eyes from healthy subjects, 30 eyes without DR, 22 eyes with minimal nonproliferative DR, 30 eyes with moderate nonproliferative DR, 16 eyes with severe nonproliferative DR, and 5 eyes with proliferative DR (PDR). The percentage of FVA-CC for each group was, respectively, 10.9 ± 3.4%, 14.6 ± 4.8%, 17.6 ± 3.5%, 20.7 ± 5.9%, 19.9 ± 2.9%, and 26.6 ± 4.4%. FVA-CC and DR stage significantly correlated (P < 0.0001). FVA-CC was significantly increased in diabetic patients without DR compared with healthy subjects (P = 0.008). CONCLUSION Diabetes is associated with quantifiable choriocapillaris alterations in swept-source optical coherence tomography angiography. These alterations precede clinical signs of DR and are correlated with DR stage. |
| Databáze: | OpenAIRE |
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