The expression of the immune checkpoint regulator VISTA correlates with improved overall survival in pT1/2 tumor stages in esophageal adenocarcinoma
| Autor: | Hakan Alakus, Philipp Lohneis, Florian Gebauer, Thomas Zander, Heike Loeser, Max Kraemer, Wolfgang Schröder, Arnulf H. Hoelscher, Oana-Diana Persa, Christiane J. Bruns, Alexander Quaas, Reinhard Buettner |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine esophageal adenocarcinoma animal diseases Immunology Regulator Esophageal adenocarcinoma chemical and pharmacologic phenomena tils lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Tumor stage Overall survival medicine Immunology and Allergy ddc:610 Receptor early tumor stages Original Research Therapeutic strategy business.industry Cancer biochemical phenomena metabolism and nutrition lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Immune checkpoint 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research bacteria vista prognosis biological phenomena cell phenomena and immunity lcsh:RC581-607 business |
| Zdroj: | OncoImmunology, Vol 8, Iss 5 (2019) Oncoimmunology |
| Popis: | Immune checkpoint modulation in cancer has been demonstrated as a high-value therapeutic strategy in many tumor entities. VISTA is an immune checkpoint receptor regulating T-cell function. To the best of our knowledge, nothing is known about the expression and prognostic impact of VISTA on tumor infiltrating lymphocytes (TILs) in the tumor microenvironment of esophageal adenocarcinoma (EAC). We analyzed in total 393 EACs within a test-cohort (n = 165) and a validation-cohort (n = 228) using a monoclonal antibody (clone D1L2G). These data were statistically correlated with clinical as well as molecular data. 22.2% of the tumor cohort presented with a VISTA expression on TILs. These patients demonstrated an improved median overall survival compared to patients without VISTA expression (202.2 months vs. 21.6 months; p |
| Databáze: | OpenAIRE |
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