Selective use of corifollitropin for controlled ovarian stimulation for IVF in patients with low anti-Müllerian hormone

Autor: Anna Pors Nielsen, Negjyp Sopa, Anne-Sofie Korsholm, Josephine Gabriela Lemmen, Anders Nyboe Andersen, Randi Sylvest
Rok vydání: 2016
Předmět:
Adult
Anti-Mullerian Hormone
0301 basic medicine
endocrine system
medicine.medical_specialty
Pregnancy Rate
endocrine system diseases
Endocrinology
Diabetes and Metabolism
media_common.quotation_subject
medicine.medical_treatment
Ovarian hyperstimulation syndrome
Fertilization in Vitro
Cohort Studies
Andrology
Ovarian Hyperstimulation Syndrome
03 medical and health sciences
0302 clinical medicine
Endocrinology
Ovulation Induction
Pregnancy
medicine
Humans
Ovulation
media_common
Gynecology
030219 obstetrics & reproductive medicine
In vitro fertilisation
biology
business.industry
Obstetrics and Gynecology
Anti-Müllerian hormone
medicine.disease
female genital diseases and pregnancy complications
Pregnancy rate
Treatment Outcome
030104 developmental biology
biology.protein
Female
Follicle Stimulating Hormone
Human
Ovulation induction
business
hormones
hormone substitutes
and hormone antagonists
Hormone
Zdroj: Gynecological Endocrinology. 32:625-628
ISSN: 1473-0766
0951-3590
DOI: 10.3109/09513590.2016.1147548
Popis: Corifollitropin, a long-acting follicle-stimulating hormone (FSH) analogue used for in vitro fertilization (IVF), does not allow individualization of dosage, and the ovarian response is similar to around 300 IU of daily recombinant FSH. This has raised concerns about the risk of ovarian hyperstimulation syndrome (OHSS) when used in standard patients. We administered corifollitropin selectively to patients with anticipated low to moderate ovarian response based on antimullerian hormone levels in the lower quartile. The end points were oocyte distribution and occurrence of OHSS in women with AMH ≤15 pmol/L. The study included a cohort of 368 patients treated in 599 cycles. Post hoc the cohort was subdivided according to AMH. With increasing baseline AMH, the number of oocytes increased from a mean of 2.7 (range 0-8 with AMH
Databáze: OpenAIRE
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