PREDICTION OF POST-RADICAL PROSTATECTOMY PATHOLOGICAL OUTCOME FOR STAGE T1c PROSTATE CANCER WITH PERCENT FREE PROSTATE SPECIFIC ANTIGEN: A PROSPECTIVE MULTICENTER CLINICAL TRIAL
| Autor: | William J. Catalona, Gail H. Gasior, Alan W. Partin, Kathleen G. Loveland, Michael K. Brawer, Anup Patel, Paula C. Southwick, Patrick C. Walsh, Robert C. Flanigan, Paul H. Lange, Jerome P. Richie, Peter T. Scardino, Robert E. Parson, Kevin M. Slawin |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Prostatectomy business.industry Urology medicine.medical_treatment Cancer urologic and male genital diseases medicine.disease Percent Free Prostate-Specific Antigen Prostate-specific antigen Prostate cancer medicine.anatomical_structure Prostate medicine Adenocarcinoma Prospective cohort study business |
| Zdroj: | Journal of Urology. 162:1346-1351 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(05)68282-1 |
| Popis: | Purpose: Prostate specific antigen (PSA) exists in bound (complexed) and unbound (free) forms in serum. The percentage of free PSA enhances the specificity of PSA testing for prostate cancer detection. We evaluated the use of percent free PSA preoperatively to predict pathological stage.Materials and Methods: A total of 379 men with prostate cancer and 394 with benign prostatic disease 50 to 75 years old were enrolled in this prospective study at 7 medical centers. All subjects had a palpably benign prostate gland, serum PSA 4.0 to 10.0 ng./ml. and a histologically confirmed diagnosis. The Hybritech Tandem§ §Hybritech, Inc., San Diego, California. PSA and free PSA assays were used. Of the 379 cancer patients 268 (71%) underwent radical prostatectomy.Results: Higher percent free PSA levels were associated with more favorable histopathological findings in prostatectomy specimens. A value of 15% free PSA provided the greatest discrimination in predicting favorable pathological outcome. Organ confined... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|