Alkylation-Terminated Catellani Reactions by Cyclobutanol C–C Cleavage
| Autor: | Ya-Ting Wen, Ming Li, Cui-Tian Wang, Rui-Qiang Jiao, Wan-Xu Wei, Ya-Nan Ding, Zhe Zhang, Xue-Ya Gou, Yong-Min Liang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Aryl Organic Chemistry Substrate (chemistry) Alkylation 010402 general chemistry Cleavage (embryo) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Cascade reaction Functional group Electrophile Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic Letters. 23:786-791 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.0c04018 |
| Popis: | This report describes the first application of a cyclobutanol ring-opening procedure in the Catellani termination reaction, which includes two β-carbon elimination processes. This tandem reaction features mild conditions, high yields, good functional group tolerance, and a broad substrate scope. Meanwhile, four types of electrophiles (N-benzoyloxyamines, alkyl iodides, aryl bromides, and benzyl chlorides) are quite compatible with this termination reaction for the construction of various types of polysubstituted aromatic hydrocarbons. |
| Databáze: | OpenAIRE |
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