The Ameliorating Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are SIRT1-Dependent: Evidence from Hepatic-Specific SIRT1 Heterozygous Mutant C57BL/6 Mice

Autor:	Yan Yin, Deming Li, Fang Liu, Xinjing Wang, Yuan Cui, Shilan Li, Xinli Li
Rok vydání:	2022
Předmět:	Flavonoids Male General Chemistry Diet High-Fat Fatty Liver Mice Inbred C57BL Mice Liver Sirtuin 1 Non-alcoholic Fatty Liver Disease Animals Female Chlorogenic Acid General Agricultural and Biological Sciences Tannins
Zdroj:	Journal of Agricultural and Food Chemistry. 70:5579-5594
ISSN:	1520-5118 0021-8561
DOI:	10.1021/acs.jafc.2c01461
Popis:	Apple polyphenol extract (APE) has been reported to possess protective effects against hepatic steatosis. To explore whether APE-induced alleviation of hepatic steatosis is SIRT1-dependent, the present study was carried out using wild-type and hepatic SIRT1 heterozygous mutant (Sirt1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389807f124c54664c48a19e4440c77fc https://doi.org/10.1021/acs.jafc.2c01461 Zobrazit plný text záznamu