Are ALOX5AP gene SNPs a risk or protective factor for stroke?
| Autor: | Maria Tzetis, K. Spengos, Emmanuel Kanavakis, Myrto Poulou, Irene Fylaktou, Apostolis Papapostolou, Ilias Gountas, Sophia Kitsiou-Tzeli |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology medicine.medical_specialty 5-Lipoxygenase-Activating Proteins Protective factor Single-nucleotide polymorphism Biology Bioinformatics Polymorphism Single Nucleotide Gene Frequency Risk Factors Diabetes mellitus Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele frequency Stroke Aged Greece Confounding Case-control study General Medicine Middle Aged medicine.disease Genotype frequency Logistic Models Case-Control Studies Female |
| Zdroj: | Gene. 548:56-60 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2014.07.007 |
| Popis: | ALOX5AP (5-lipoxygenase) has been recognized as a susceptibility gene for stroke. Using a case-control design, the whole coding and adjoining intronic regions of ALOX5AP were sequenced to study the role of SNPs and their interplay with other risk factors in Greek patients with stroke. Patients (n=213) were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Their mean age of was 58.9 ± 14.64, comprising 145 males. The control group consisted of 210 subjects, ethnicity, sex and age matched, with no stroke history. Risk factors (hyperlipidemia, hypertension, atrial fibrillation, migraine, CAD, diabetes, smoking and alcohol consumption) were assessed as confounding factors and comparisons were done using logistic regression analysis. SNPs rs4769055, rs202068154 and rs3803277 located in intronic regions of the gene and according to in silico programs EX_SKIP and HSF possibly affecting splicing of exons 1 and 2 of ALOX5AP, showed significantly different frequencies between patients and controls. The genotype frequencies of rs4769055: AA, of rs202068154: AC and of rs3803277: CA were significantly higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect