Clinical features of childhood diabetes mellitus focusing on latent autoimmune diabetes
| Autor: | Seung Ho Lee, Jeesuk Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Age at diagnosis 030209 endocrinology & metabolism Gastroenterology 03 medical and health sciences 0302 clinical medicine Autoantibody Internal medicine Type 2 diabetes mellitus Medicine Childhood Diabetes Mellitus 030212 general & internal medicine Child business.industry Insulin Clinical course lcsh:RJ1-570 Type 2 Diabetes Mellitus lcsh:Pediatrics Endocrinology Autoimmune diabetes Pediatrics Perinatology and Child Health Original Article business |
| Zdroj: | Annals of Pediatric Endocrinology & Metabolism, Vol 21, Iss 4, Pp 212-218 (2016) Annals of Pediatric Endocrinology & Metabolism |
| ISSN: | 2287-1292 2287-1012 |
| Popis: | PURPOSE This study was designed to evaluate the clinical characteristics of childhood diabetes mellitus (DM) according to its classification as well as the clinical course of latent autoimmune diabetes (LAD) that initially showed noninsulin dependence despite autoantibody positivity. METHODS A total of 91 subjects diagnosed between 2001 and 2015 were enrolled in the study. They were classified into 3 groups: type 1 DM, LAD, and type 2 DM. Clinical features and laboratory findings were compared among groups. RESULTS Among 91 subjects, type 1 DM, LAD, and type 2 DM were 51 (56.0%), 7 (7.7%), and 33 (36.3%), respectively. In LAD, age at diagnosis and BMI Z-scores were higher, as compared with those in type 1 DM. Initial serum c-peptide levels were higher in LAD than those in type 1 DM, but lower than those in type 2 DM. In LAD, the mean follow-up duration was 4.56 years, and 43% of the patients ultimately required intensive insulin treatment with dosage of > 0.5 U/kg/day. HbA1C and serum c-peptide levels at the time of intensive insulin treatment were 9.43±0.93% and 1.37±1.36 ng/mL, respectively. Recent serum c-peptide/glucose ratio was lower in the group requiring intensive insulin treatment than the group without intensive insulin treatment, with P-value of 0.057 (0.003±0.005 vs. 0.071±0.086). CONCLUSION Initial autoantibody evaluation is useful for classification and management. Close monitoring of the patients with LAD is important due to the expected need for intensive insulin treatment within several years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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