Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease
| Autor: | Françoise Delacrétaz, G Michel, C. Meugé‐Moraw, A.S. Baur |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Adolescent medicine.drug_class Disease Monoclonal antibody Pathology and Forensic Medicine Biomarkers Tumor medicine Humans Reed-Sternberg Cells Grading (tumors) Survival rate Aged Retrospective Studies Aged 80 and over Follicular dendritic cells business.industry Retrospective cohort study Dendritic Cells General Medicine Middle Aged Prognosis medicine.disease Hodgkin Disease Immunohistochemistry Lymphoma Survival Rate Multivariate Analysis Female Lymph Nodes business |
| Zdroj: | Histopathology. 32:512-520 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1046/j.1365-2559.1998.t01-1-00418.x |
| Popis: | Aims In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low-grade) and NSII (high-grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. Methods and results Tumours from 59 patients with NSHD were studied. Mean follow-up time was 8 years. Forty-one cases were classified as NSI and 18 as NSII. FDC were immunostained with the paraffin-resistant monoclonal antibodies CD21 and CNA.42. We distinguished three patterns in the neoplastic tissue: FDC1, the presence of well-defined follicle-like structures (n = 20); FDC2, the presence of largely destroyed FDC networks (n = 25); and FDC3, no or a few isolated FDC (n = 14). The three groups differed clearly regarding the frequency of relapse and the survival. The longest survival was seen in the FDC1 group, the shortest in the FDC3 group, the FDC2 group being intermediate (P = 0.0025). FDC status was a discriminating prognostic factor for all patients, and within various age and stage categories. Combining the FDC status and the NSI–NSII grading defined the best survival group as FDC1-NSI. Conclusions Assessment of FDC pattern, associated with histological subtyping, brings valuable data for predicting survival and outcome in NSHD. |
| Databáze: | OpenAIRE |
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