Clinical Trials of Bivalent Influenza A/New Jersey/76-A/Victoria/75 Vaccines in the Elderly
| Autor: | Vernon Knight, Howard R. Six, Robert B. Couch, Thomas R. Cate, Julius A. Kasel |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Aging Fever Dose-Response Relationship Immunologic Antibodies Viral Virus Bivalent (genetics) Double-Blind Method Antigen Humans Immunology and Allergy Medicine Aged Clinical Trials as Topic Reactogenicity New Jersey biology business.industry Hemagglutination Inhibition Tests Middle Aged Virology Clinical trial Vaccination Titer Infectious Diseases England Erythema Influenza A virus Influenza Vaccines Immunology biology.protein Female Antibody business |
| Zdroj: | Journal of Infectious Diseases. 136:S518-S525 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | This placebo-controlled evaluation in elderly persons of inactivated influenza virus vaccines containing 200 or 400 chicke cell-agglutinating units of both A/New Jersey/76 and A/Victoria/75 antigens revealed mild systemic reactions in 7.8% and moderate reactions in 4.9% of vaccinees. These reactions were more common after administration of whole-virus than subvirion vaccines, more frequent in females than males, and more frequent in persons with low initial titers of antibody to A/New Jersey antigen. Local inflammation occurred in 18.7% of vaccinees (predominantly females) and frequently was seen with systemic reactions, but did not correlate with antibody response. Titers of antibody to A/New Jersey antigen were initially high and 99% of vaccinees had titers of greater than 1:20 after vaccination. Titers of antibody to A/Victoria antigen were initially low, and 56% of vaccinees had titers of greater than 1:20 after vaccination. Fourfold or greater increases in titer occurred in about 50% of vaccinees for each virus, most often concomitantly. Antibody responses to subvirion and whole-virus vaccines were similar, and increased responses with higher doses coincided with increased reactogenicity. Later revaccinations because of low titers of A/Victoria antibody produced negligible antibody responses. |
| Databáze: | OpenAIRE |
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