Dominant neurologic symptomatology in intravascular large B-cell lymphoma
| Autor: | Pavel Babal, A Steno, Peter Martanovič, Z Tomleinova, K. Kubišová, Boris Rychly, V Sisovsky, Pavol Janega |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Economics and Econometrics Pathology medicine.medical_specialty Vision Disorders Disease 03 medical and health sciences 0302 clinical medicine Paraparesis Aphasia Materials Chemistry Media Technology medicine Humans In patient Spinal Cord Neoplasms Histological examination Aged 80 and over Intravascular large B-cell lymphoma Brain Neoplasms business.industry Forestry Middle Aged medicine.disease Spinal cord Vascular Neoplasms Lymphoma 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Etiology Sphincter Autopsy Lymphoma Large B-Cell Diffuse business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1336-0345 |
| DOI: | 10.4149/bll_2016_061 |
| Popis: | Intravascular large B-cell lymphoma (IVLBCL) is a rare variant of extranodal large B-cell lymphoma and it is characterized by selective intravascular proliferation of malignant cells. Typical features of the disease include aggressive behavior, rapid and frequently fatal course. Clinical picture is non-specific and heterogeneous, depending on the affected organ. It is not uncommon that this unique type of lymphoma is diagnosed post mortem. Herein, we report two cases of IVLBCL with neurologic symptomatology. In our clinical study patient 1 was an 80-year-old male with mixed paraparesis of lower extremities and difficulties with sphincter control. Patient 2 (56-year-old male) had vision malfunction, mental status changes and defect in phatic and motor functions. In both cases definite diagnosis was established by histological examination of necroptic material. We propose to include IVLBCL in differential diagnostic considerations in patients presenting with gradually impairing neurological status and spinal cord damage of unknown etiology (Fig. 2, Ref. 9). |
| Databáze: | OpenAIRE |
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