Cutaneous Melanoma Systematic Diagnostic Workflows and Integrated Reflectance Confocal Microscopy Assessed with a Retrospective, Comparative Longitudinal (2009–2018) Study
| Autor: | Giovanni Pellacani, Francesca Farnetani, Johanna Chester, Shaniko Kaleci, Silvana Ciardo, Sara Bassoli, Alice Casari, Caterina Longo, Marco Manfredini, Anna Maria Cesinaro, Francesca Giusti, Antonio Iacuzio, Mario Migaldi |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Cancer Research
skin cancer Cancer patient pathways Epidemiology Health services research Melanoma Number needed to excise Skin cancer cancer patient pathways Neoplasms. Tumors. Oncology. Including cancer and carcinogens health services research Oncology melanoma epidemiology number needed to excise RC254-282 |
| Zdroj: | Cancers; Volume 14; Issue 3; Pages: 838 Cancers, Vol 14, Iss 838, p 838 (2022) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14030838 |
| Popis: | Background: The increasing global burden of melanoma demands efficient health services. Accurate early melanoma diagnosis improves prognosis. Objectives: To assess melanoma prevention strategies and a systematic diagnostic-therapeutical workflow (improved patient access and high-performance technology integration) and estimate cost savings. Methods: Retrospective analysis of epidemiological data of an entire province over a 10-year period of all excised lesions suspicious for melanoma (melanoma or benign), registered according to excision location: reference hospital (DP) or other (NDP). A systematic diagnostic-therapeutical workflow, including direct patient access, primary care physician education and high-performance technology (reflectance confocal microscopy (RCM)) integration, was implemented. Impact was assessed with the number of lesions needed to excise (NNE). Results: From 40,832 suspicious lesions excised, 7.5% (n = 3054) were melanoma. There was a 279% increase in the number of melanomas excised (n = 203 (2009) to n = 567 (2018)). Identification precision improved more than 100% (5.1% in 2009 to 12.0% in 2018). After RCM implementation, NNE decreased almost 3-fold at DP and by half at NDP. Overall NNE for DP was significantly lower (NNE = 8) than for NDP (NNE = 20), p < 0.001. Cost savings amounted to EUR 1,476,392.00. Conclusions: Melanoma prevention strategies combined with systematic diagnostic-therapeutical workflow reduced the ratio of nevi excised to identify each melanoma. Total costs may be reduced by as much as 37%. |
| Databáze: | OpenAIRE |
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