Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes
Autor: | Katerina Kankova, Lukas Pacal, Katarína Chalásová, Vendula Bartáková, Anna Pleskačová, Josef Tomandl |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_treatment 030204 cardiovascular system & hematology lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine lcsh:QH301-705.5 Spectroscopy 2. Zero hunger Obstetrics Pregnancy Outcome Gestational age General Medicine gestational diabetes mellitus 3. Good health Computer Science Applications Gestational diabetes uricemia xanthine Female pregnancy Adult medicine.medical_specialty Single-nucleotide polymorphism Article Catalysis Inorganic Chemistry 03 medical and health sciences uric acid adverse perinatal outcomes medicine Humans Physical and Theoretical Chemistry Molecular Biology Pregnancy business.industry Insulin Organic Chemistry medicine.disease Obesity Diabetes Gestational 030104 developmental biology chemistry lcsh:Biology (General) lcsh:QD1-999 Case-Control Studies Uric acid business Body mass index Biomarkers |
Zdroj: | International Journal of Molecular Sciences Volume 19 Issue 11 International Journal of Molecular Sciences, Vol 19, Iss 11, p 3696 (2018) |
ISSN: | 1422-0067 |
DOI: | 10.3390/ijms19113696 |
Popis: | Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes. |
Databáze: | OpenAIRE |
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