Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes

Autor: Katerina Kankova, Lukas Pacal, Katarína Chalásová, Vendula Bartáková, Anna Pleskačová, Josef Tomandl
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_treatment
030204 cardiovascular system & hematology
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
lcsh:QH301-705.5
Spectroscopy
2. Zero hunger
Obstetrics
Pregnancy Outcome
Gestational age
General Medicine
gestational diabetes mellitus
3. Good health
Computer Science Applications
Gestational diabetes
uricemia
xanthine
Female
pregnancy
Adult
medicine.medical_specialty
Single-nucleotide polymorphism
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
uric acid
adverse perinatal outcomes
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
Pregnancy
business.industry
Insulin
Organic Chemistry
medicine.disease
Obesity
Diabetes
Gestational
030104 developmental biology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Case-Control Studies
Uric acid
business
Body mass index
Biomarkers
Zdroj: International Journal of Molecular Sciences
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3696 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19113696
Popis: Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje