Aerobic capacity over 16 years in patients with rheumatoid arthritis: Relationship to disease activity and risk factors for cardiovascular disease
| Autor: | Solbritt Rantapää-Dahlqvist, Kristina Hörnberg, Lena Innala, Solveig Wållberg-Jonsson, Björn Sundström |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Physiology Adipose tissue lcsh:Medicine Blood Pressure Disease Cardiovascular Medicine 030204 cardiovascular system & hematology Vascular Medicine Arthritis Rheumatoid 0302 clinical medicine Heart Rate Risk Factors Medicine and Health Sciences Public and Occupational Health skin and connective tissue diseases lcsh:Science Multidisciplinary Middle Aged Sports Science Physiological Parameters Adipose Tissue Cardiovascular Diseases Rheumatoid arthritis Female Anatomy Research Article Adult medicine.medical_specialty Immunology Cardiology Rheumatoid Arthritis Autoimmune Diseases Disease activity 03 medical and health sciences Rheumatology Internal medicine Heart rate medicine Humans In patient Sports and Exercise Medicine Exercise Aerobic capacity Rheumatology and Autoimmunity 030203 arthritis & rheumatology Reumatologi och inflammation business.industry Arthritis Body Weight lcsh:R Biology and Life Sciences Physical Activity medicine.disease Biological Tissue Blood pressure Physical Fitness Clinical Immunology lcsh:Q sense organs Clinical Medicine business Follow-Up Studies |
| Zdroj: | PLoS ONE, Vol 12, Iss 12, p e0190211 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The aim of this study was to analyse the change in aerobic capacity from disease onset of rheumatoid arthritis (RA) over 16.2 years, and its associations with disease activity and cardiovascular risk factors. Twenty-five patients (20 f/5 m), diagnosed with RA 1995-2002 were tested at disease onset and after mean 16.2 years. Parameters measured were: sub-maximal ergometer test for aerobic capacity, functional ability, self-efficacy, ESR, CRP and DAS28. At follow-up, cardiovascular risk factors were assessed as blood lipids, glucose concentrations, waist circumference, body mass index (BMI), body composition, pulse wave analysis and carotid intima-media thickness. Aerobic capacity [median (IQR)] was 32.3 (27.9-42.1) ml O2/kg x min at disease onset, and 33.2 (28.4-38.9) at follow-up (p>0.05). Baseline aerobic capacity was associated with follow-up values of: BMI (rs = -.401, p = .047), waist circumference (rs = -.498, p = .011), peripheral pulse pressure (rs = -.415, p = .039) self-efficacy (rs = .420, p = .037) and aerobic capacity (rs = .557, p = .004). In multiple regression models adjusted for baseline aerobic capacity, disease activity at baseline and over time predicted aerobic capacity at follow-up (AUC DAS28, 0-24 months; β = -.14, p = .004). At follow-up, aerobic capacity was inversely associated with blood glucose levels (rs = -.508, p = .016), BMI (rs = -.434, p = .030), body fat% (rs = -.419, p = .037), aortic pulse pressure (rs = -.405, p = .044), resting heart rate (rs = -.424, p = .034) and self-efficacy (rs = .464, p = .020) at follow-up. We conclude that the aerobic capacity was maintained over 16 years. High baseline aerobic capacity associated with favourable measures of cardiovascular risk factors at follow-up. Higher disease activity in early stages of RA predicted lower aerobic capacity after 16.2 years. |
| Databáze: | OpenAIRE |
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