Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

Autor:	Christina A. Svitek, James K. Oeser, Richard M. O'Brien, Angela Eeds, Beth T. Stadelmaier, Peter O. Wiebe, Jared N. Boustead
Jazyk:	angličtina
Rok vydání:	2003
Předmět:	Transcription Genetic Interleukin 5 receptor alpha subunit Receptors Cytoplasmic and Nuclear Biochemistry Gene Expression Regulation Enzymologic Interleukin 10 receptor alpha subunit Mice Catalytic Domain Tumor Cells Cultured Animals Hepatocyte nuclear factor 4 gamma Promoter Regions Genetic Molecular Biology Nuclear receptor co-repressor 1 DNA Primers Sequence Deletion Binding Sites Base Sequence Chemistry Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Cell Biology Phosphoproteins Molecular biology Precipitin Tests DNA-Binding Proteins Hepatocyte nuclear factor 4 Hepatocyte Nuclear Factor 4 Hepatocyte nuclear factor 4 alpha Glucose-6-Phosphatase Peroxisome proliferator-activated receptor delta Peroxisome proliferator-activated receptor alpha Research Article Protein Binding Transcription Factors
Popis:	It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1 alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4 alpha.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388ab0acd72755f0f05de30c3aa32342 https://europepmc.org/articles/PMC1223073/ Zobrazit plný text záznamu