Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas
| Autor: | Shaomei Geng, Shucheng Ma, Shengkui Lu, Zhaohui Liang, Shuai Wang, Baohua Jiao |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male Cancer Research Pathology medicine.medical_specialty Adolescent Kaplan-Meier Estimate Astrocytoma Pathology and Forensic Medicine law.invention Young Adult law Internal medicine microRNA medicine Biomarkers Tumor Humans Clinical significance neoplasms Pathological Polymerase chain reaction Aged Proportional hazards model business.industry Brain Neoplasms General Medicine Middle Aged medicine.disease Prognosis nervous system diseases MicroRNAs Apoptosis Case-Control Studies Disease Progression Ectopic expression Female business |
| Zdroj: | Pathology oncology research : POR. 20(2) |
| ISSN: | 1532-2807 |
| Popis: | MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. More recently, it has been demonstrated that the ectopic expression of miR-206 significantly inhibited the proliferation and promoted apoptosis at the early stages in glioma cell U343. In order to investigate the clinical significance of miR-206 expression in human astrocytoma, quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-206 in 108 astrocytoma and 20 normal brain tissues. As the results, the expression levels of miR-206 in astrocytoma tissues were significantly lower than those in normal brain tissues (P |
| Databáze: | OpenAIRE |
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