An update on complex I assembly: the assembly of players

Autor:	Rasika Vartak, Yidong Bai, Manpreet K. Semwal
Rok vydání:	2014
Předmět:	Genetics Electron Transport Complex I Mitochondrial Diseases Physiology Extramural Cell Biology Computational biology Biology Article Mitochondrial Proteins Human disease Mutation Animals Humans Large size
Zdroj:	Journal of Bioenergetics and Biomembranes. 46:323-328
ISSN:	1573-6881 0145-479X
Popis:	Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Mutations in Complex I subunits as well as assembly factors have been reported to hinder its assembly and give rise to a range of mitochondria disorders. In this review, we summarize the recent progress made in understanding the Complex I assembly pathway. In particularly, we focus on the known as well as novel assembly factors and their role in assembly of Complex I and human disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388a452b155cdbfe1e79236b73f6718b https://doi.org/10.1007/s10863-014-9564-x Zobrazit plný text záznamu Full text from SpringerLink