An update on complex I assembly: the assembly of players
Autor: | Rasika Vartak, Yidong Bai, Manpreet K. Semwal |
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Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Journal of Bioenergetics and Biomembranes. 46:323-328 |
ISSN: | 1573-6881 0145-479X |
Popis: | Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Mutations in Complex I subunits as well as assembly factors have been reported to hinder its assembly and give rise to a range of mitochondria disorders. In this review, we summarize the recent progress made in understanding the Complex I assembly pathway. In particularly, we focus on the known as well as novel assembly factors and their role in assembly of Complex I and human disease. |
Databáze: | OpenAIRE |
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