Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart
| Autor: | Atsushi Miyanohara, Tracy Guo, Dimosthenis Giamouridis, Matthijs Blankesteijn, H. Kirk Hammond, Erik A.L. Biessen, Young Chul Kim, N. Chin Lai, Mei Hua Gao, Zhen Tan |
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| Přispěvatelé: | Farmacologie en Toxicologie, RS: Carim - H03 ECM and Wnt signaling, RS: CARIM - R2 - Cardiac function and failure, RS: Carim - B07 The vulnerable plaque: makers and markers, Pathologie, RS: CARIM - R3 - Vascular biology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
PHARMACOKINETICS medicine.medical_treatment Gene Expression Apoptosis MOUSE Sarcomere Ventricular Function Left Mice 0302 clinical medicine Transduction Genetic Troponin I Gene Order Myocyte FAILURE Myocytes Cardiac Myocardial infarction Transgenes Saline Urocortins Research Articles Urocortin 0303 health sciences Ejection fraction Gene Transfer Techniques Dependovirus MUSCLE gene therapy Echocardiography 030220 oncology & carcinogenesis Cardiology Molecular Medicine Female AAV8 ADENOASSOCIATED VIRUS VECTORS EXPRESSION medicine.medical_specialty Genetic Vectors 03 medical and health sciences Internal medicine heart failure with reduced EF Genetics medicine Animals Molecular Biology 030304 developmental biology Heart Failure business.industry Genetic Therapy medicine.disease Fibrosis DYSFUNCTION Disease Models Animal MYOCARDIAL-INFARCTION Heart failure Calcium business SERCA2a Biomarkers |
| Zdroj: | Human Gene Therapy, 30(1), 10-20. Mary Ann Liebert Inc. |
| ISSN: | 1043-0342 |
| Popis: | Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. This study asked whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases the function of the failing heart. HF was induced by transmural left ventricular (LV) cryoinjury in mice. LV function was assessed 3 weeks later by echocardiography. Those with ejection fractions (EF) |
| Databáze: | OpenAIRE |
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