Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species
| Autor: | C. Toskulkac, L. Chaturat, P. Temcharoen, T. Glinsukon |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Hamster Steviol Toxicology Kidney Median lethal dose Blood Urea Nitrogen Lethal Dose 50 chemistry.chemical_compound Mice Sex Factors Glucosides Species Specificity Internal medicine Cricetinae medicine Animals Tissue Distribution Stevioside Aspartate Aminotransferases Rats Wistar Pharmacology Chemical Health and Safety biology Mesocricetus Terpenes Public Health Environmental and Occupational Health Alanine Transaminase General Medicine Blood Proteins Acute Kidney Injury biology.organism_classification Acute toxicity Rats Stevia rebaudiana Endocrinology chemistry Liver Creatinine Sweetening Agents Toxicity Female Diterpenes Diterpenes Kaurane |
| Zdroj: | Drug and chemical toxicology. 20(1-2) |
| ISSN: | 0148-0545 |
| Popis: | The acute toxicity of stevioside and steviol (a product of enzymatic hydrolysis of stevioside) was investigated in three animal species including rat, mouse and hamster. The susceptibility to stevioside and steviol acute toxicity in both sexes of these animal species was compared. The animals were treated intragastrically with stevioside or steviol and general signs and symptoms were observed. The numbers of dead animals were recorded within a period of 14 days after administration for estimation of LD50. Stevioside at a dose as high as 15 g/kg BW was not lethal to either mice, rats or hamsters. Hamsters were found to be more susceptible to steviol than rats or mice. LD50 values of steviol in hamsters were 5.20 and 6.10 g/kg BW for males and females, respectively. In rats and mice, LD50 values of steviol were higher than 15 g/kg BW in both sexes. Histopathological examination in the kidney of hamsters induced by steviol revealed severe degeneration of the proximal tubular cells. These structural alterations were correlated with the increases in serum blood urea nitrogen (BUN) and creatinine. Therefore, the possible cause of death induced by steviol might be due to acute renal failure. |
| Databáze: | OpenAIRE |
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