Comparing Radiotherapy to Prostatectomy for High-Risk Prostate Cancer
| Autor: | Victor Chen, James M. Taylor, Robert B. Den, Benjamin A. Greenberger |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty medicine.medical_treatment Brachytherapy Disease-Free Survival Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Meta-Analysis as Topic medicine Humans Combined Modality Therapy Patient Reported Outcome Measures Intensive care medicine Randomized Controlled Trials as Topic Prostatectomy business.industry Prostate Prostatic Neoplasms Androgen Antagonists Chemoradiotherapy medicine.disease Radiation therapy Observational Studies as Topic 030104 developmental biology Oncology 030220 oncology & carcinogenesis Disease Progression Quality of Life Prostate surgery Observational study business |
| Zdroj: | The Cancer Journal. 26:29-37 |
| ISSN: | 1540-336X 1528-9117 |
| DOI: | 10.1097/ppo.0000000000000420 |
| Popis: | There is currently a lack of level 1 evidence regarding the relative efficacy of radical prostatectomy compared with radiotherapy combined with androgen deprivation therapy for high-risk prostate cancer. There has recently been an improved optimization of treatment, achieving superior biochemical outcomes and cancer-specific mortality through the use of combined modality therapy strategies. Combined modality therapies have also increasingly incorporated brachytherapy boost. Although available observational data must be interpreted with caution because of the effects of potential residual confounding, we present here a narrative review of recent advances in understanding the relative efficacy of the principal combined modality approaches for treating high-risk prostate cancer. As the trend has demonstrated approaching equivalence between well-selected combined modality therapies, an increasing emphasis should be placed on selecting therapy tailored toward a patient's goals regarding quality of life. We present here an outline of efforts to date to understand the implications of treatment on functional outcomes and quality-of-life endpoints. |
| Databáze: | OpenAIRE |
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