Interleukin-18 Is Elevated in the Sera from Patients with Atopic Dermatitis and from Atopic Dermatitis Model Mice, NC/Nga
| Autor: | Way Wang, Mayumi Kotani, Kenji Nakanishi, Shinji Higa, Akihito Fujita, Masaki Suemura, Tadamitsu Koshimoto, Toshio Tanaka, Tomohiro Yoshimoto, Hiroko Tsutsui, Motonobu Matsumoto |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Allergy Adolescent medicine.medical_treatment Immunology Inflammation macromolecular substances Dermatitis Atopic Atopy Mice In vivo medicine Animals Humans Immunology and Allergy business.industry Interleukin-18 General Medicine Atopic dermatitis Immunoglobulin E medicine.disease In vitro Specific Pathogen-Free Organisms Disease Models Animal Cytokine Interleukin 18 medicine.symptom business |
| Zdroj: | International Archives of Allergy and Immunology. 125:236-240 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000053821 |
| Popis: | Background: Several lines of in vitro and in vivo studies have demonstrated that interleukin-18 (IL-18) shows both antiallergic and allergy-promoting activities. But its expression in allergic diseases remains unknown. Methods: Serum IL-18 levels from atopic dermatitis (AD) model mice, NC/Nga and control mice and from patients with AD and healthy volunteers were measured by ELISA. The relationship between IL-18 levels and serum IgE levels or clinical severity was also examined. Results: Serum IL-18 levels from NC/Nga mice were significantly increased compared to those from control mice. The elevation of IL-18 in the sera was observed prior to the onset and during the development of dermatitis in NC/Nga mice. In addition, IL-18 levels in the sera from patients with AD were significantly (p < 0.05) elevated compared to those from healthy volunteers. However, serum IL-18 levels tended to correlate negatively with serum IgE levels in patients with AD and NC/Nga mice. Conclusion: IL-18 is overexpressed in AD. |
| Databáze: | OpenAIRE |
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