IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
| Autor: | Michael D. Green, Timothy L. Frankel, Weiping Zou, Wan Du |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
IFNGR
PD-L1 Colorectal cancer medicine.medical_treatment T cell Immunology Apoptosis Review Article Interferon-gamma Immunity PD-1 Tumor Microenvironment Humans Ferroptosis Immunology and Allergy Medicine Interferon gamma EZH2 biology business.industry Immunotherapy medicine.disease ARID1A Immune checkpoint Protein Transport Infectious Diseases medicine.anatomical_structure Oncology Cancer research biology.protein Interferon MHC Signal transduction Colorectal Neoplasms business Palmitoylation Immunosuppression Signal Transduction medicine.drug |
| Zdroj: | Cellular and Molecular Immunology |
| ISSN: | 2042-0226 1672-7681 |
| Popis: | The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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