Protective Effect of Vitamin E Against Ethanol-Induced Hyperhomocysteinemia, DNA Damage, and Atrophy in the Developing Male Rat Brain
| Autor: | Alireza Shirpoor, Syranush Minassian, Marine Yegiazarian, Mohammad Hassan Khadem-Ansari, Siamak Salami |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Hyperhomocysteinemia DNA damage Offspring medicine.medical_treatment Excitotoxicity Medicine (miscellaneous) Biology Toxicology medicine.disease_cause chemistry.chemical_compound Atrophy Pregnancy Internal medicine medicine Animals Vitamin E Rats Wistar Ethanol Brain medicine.disease Rats Oxidative Stress Psychiatry and Mental health Neuroprotective Agents Endocrinology Animals Newborn nervous system chemistry Prenatal Exposure Delayed Effects Female Oxidative stress DNA Damage |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 33:1181-1186 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.2009.00941.x |
| Popis: | Background: Chronic alcoholism leads to elevated plasma and brain homocysteine (Hcy) levels, as demonstrated by clinical investigations and animal experiments. It has been posited that elevated levels of Hcy mediate DNA damage, brain atrophy, and excitotoxicity. The current study sought to elucidate the effect of vitamin E on ethanol-induced hyperhomocysteinemia, DNA damage, and atrophy in the developing hippocampus and cerebellum of rats. Methods: Pregnant Wistar rats received ethanol with or without vitamin E from gestation day 7 throughout lactation. Weight changes in the brain, hippocampus and cerebellum, DNA damage, and Hcy levels in the plasma, hippocampus, and cerebellum of male offspring were measured at the end of lactation. Results: The results revealed that along with a significant decrease in brain, cerebellum, and hippocampus weights in animals that received alcohol, the levels of DNA damage and Hcy significantly increased. Significant amelioration of brain atrophy and DNA damage as well as restoration of the elevated level of Hcy to that of controls were found in vitamin E-treated rats. Conclusions: These findings strongly support the idea that ethanol intake by dams during pregnancy and lactation induces Hcy-mediated oxidative stress in the developing hippocampus and cerebellum of offspring rats, and that these effects can be alleviated by vitamin E as an antioxidant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text