The GABAergic system as a therapeutic target for Alzheimer's disease
| Autor: | Chitra Vinnakota, Richard L.M. Faull, Karan Govindpani, Henry J. Waldvogel, Andrea Kwakowsky, Beatriz Calvo-Flores Guzmán |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Disease Inhibitory postsynaptic potential Biochemistry gamma-Aminobutyric acid 03 medical and health sciences Cellular and Molecular Neuroscience Glutamatergic 0302 clinical medicine Alzheimer Disease medicine Animals Humans gamma-Aminobutyric Acid business.industry medicine.disease 030104 developmental biology Drug development Cholinergic GABAergic Alzheimer's disease business Neuroscience 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Journal of Neurochemistry. 146:649-669 |
| ISSN: | 0022-3042 |
| DOI: | 10.1111/jnc.14345 |
| Popis: | Glutamatergic and cholinergic dysfunction are well-attested features of Alzheimer's disease (AD), progressing with other pathological indices of the disorder and exacerbating neuronal and network dysfunction. However, relatively little attention has been paid to the inhibitory component of the excitatory/inhibitory (E/I) network, particularly dysfunction in the gamma-aminobutyric acid (GABA) signaling system. There is growing evidence in support of GABAergic remodeling in the AD brain, potentially beginning in early stages of disease pathogenesis, and this could thus be a valid molecular target for drug development and pharmacological therapies. Several GABAergic drugs have been tested for efficacy in attenuating or reversing various features and symptoms of AD, and this could represent a novel path by which we might address the growing need for more effective and benign therapies. |
| Databáze: | OpenAIRE |
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