Thyrotropin variations may explain some positive radioiodine therapy scans in patients with negative diagnostic scans
| Autor: | J. Y. Devaux, I. Keller, E. Hindié, P. Zanotti-Fregonara, Domenico Rubello, M. Calzada-Nocaudie |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Urology Levothyroxine Thyrotropin Carcinoma Papillary Follicular Iodine Radioisotopes Endocrinology Text mining medicine Humans Whole Body Imaging In patient Thyroid Neoplasms Radionuclide Imaging False Negative Reactions Thyroid cancer Retrospective Studies business.industry Thyroid Radioiodine therapy Middle Aged medicine.disease Radiography medicine.anatomical_structure Female Thyroglobulin business Nuclear medicine Empiric therapy Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Endocrinological Investigation. 32:267-271 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03346465 |
| Popis: | Thyroglobulin (Tg) is a specific marker of residual thyroid cancer or tumor recurrence. In patients with elevated Tg levels and negative diagnostic radioiodine (131I) whole-body scans (dWBS), administration of a therapy dose may reveal foci that were not initially apparent. The aim of this study was to identify factors, other than 131I activity, which might explain why a post-therapy 131I whole-body scan is sometimes positive despite a negative dWBS. Patients and methods: We reviewed data on all patients with elevated Tg levels and negative dWBS with 185 MBq 131I Off-T4 at followup, who subsequently received an empiric therapy dose of 3700 MBq of 131I. During a 5-yr period, 22 patients met these criteria. 131I therapy could be given immediately after negative dWBS in 9 patients, with an average of 8 extra days of hypothyroidism. In the other 13 patients, therapy was given an average of 8 months later. Results: The therapy scan was negative in 16 patients, while it showed uptake in the thyroid bed in 5 patients and distant metastases in two. In the latter two patients, the TSH level was suboptimal at the time of dWBS (9 and 25 μlU/ml), and had risen to 34 and 70 μlU/ml respectively at the time of therapy. Overall, a positive scan following therapy occurred in 7 patients (6/9 patients treated immediately and 1/13 patients treated in a separate setting; p |
| Databáze: | OpenAIRE |
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