Effects of melatonin administration on oxidative stress and daily locomotor activity patterns in goldfish
| Autor: | Juan Antonio Madrid, Francisco Javier Sánchez-Vázquez, María J. Bayarri, José Fernando López-Olmeda, M. A. Rol de Lama |
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| Rok vydání: | 2006 |
| Předmět: |
Lipid Peroxides
endocrine system medicine.medical_specialty Antioxidant Physiology medicine.medical_treatment Motor Activity Biology medicine.disease_cause Biochemistry Locomotor activity Lipid peroxidation Melatonin chemistry.chemical_compound Goldfish Internal medicine medicine Animals Hypoxia Hydrogen peroxide Behavior Animal Hydrogen Peroxide General Medicine Hypoxia (medical) In vitro Circadian Rhythm Oxidative Stress Endocrinology Liver chemistry Muscle Fibers Fast-Twitch Lipid Peroxidation medicine.symptom hormones hormone substitutes and hormone antagonists Oxidative stress medicine.drug |
| Zdroj: | Journal of Physiology and Biochemistry. 62:17-25 |
| ISSN: | 1877-8755 1138-7548 |
| DOI: | 10.1007/bf03165802 |
| Popis: | Melatonin has a number of physiological functions in addition to light-dark transduction. In recent years, many in vivo and in vitro studies in rodents have revealed an important antioxidant activity of melatonin, both directly and indirectly. Nevertheless, the potential effects of melatonin as an antioxidant in fish remain unknown. The aim of this research was to evaluate the capacity of melatonin injections (3 mg/kg) to attenuate oxidative damage after submitting goldfish to oxidative stress caused directly by hydrogen peroxide (H2O2) baths and indirectly by hypoxia and subsequent reoxygenation, as well as the locomotor activity. The results revealed that melatonin decreased lipid damage in muscle after hypoxia/reoxygenation (1.22 vs. 2.27 nmoles lipid peroxides/g tissue), but not in liver. Mortality caused by oxidative stress was not attenuated by melatonin. Surprisingly, melatonin caused an increase of mortality (50 vs. 95%) when administered before hypoxia. Locomotor activity was also affected by melatonin but not by the administration of the vehicle, suggesting a sedative effect of melatonin in goldfish. In conclusion, melatonin administration provoked slight effects on lipid peroxidation and mortality resulting from oxidative stress, with reduction of locomotor activity in relation to the vehicle. |
| Databáze: | OpenAIRE |
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