Relationship between vitamin D status and clinical outcomes in dogs with a cranial cruciate ligament rupture
| Autor: | Susan Campbell, Ian Handel, John Ryan, Emma Hurst, Adam Gow, Dylan N. Clements, Richard J. Mellanby |
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| Rok vydání: | 2020 |
| Předmět: |
Elective orthopaedic surgery
Male medicine.medical_specialty 040301 veterinary sciences Radiography Population vitamin D Gastroenterology 0403 veterinary science Cruciate ligament Cohort Studies 03 medical and health sciences Dogs Disease severity Internal medicine medicine Vitamin D and neurology Animals Dog Diseases Serum 25 hydroxyvitamin d Anterior Cruciate Ligament Vitamin D education 030304 developmental biology 0303 health sciences education.field_of_study General Veterinary Rupture Spontaneous business.industry Anterior Cruciate Ligament Injuries 04 agricultural and veterinary sciences Vitamins 25 hydroxyvitamin D medicine.anatomical_structure Treatment Outcome cranial cruciate ligament rupture Lameness dog Female business |
| Zdroj: | Clements, D, Ryan, J, Handel, I, Gow, A, Campbell, S, Hurst, E & Mellanby, R 2021, ' Relationship between vitamin D status and clinical outcomes in dogs with a cranial cruciate ligament rupture ', Research in Veterinary Science . https://doi.org/10.1016/j.rvsc.2021.03.019 |
| ISSN: | 1532-2661 |
| DOI: | 10.1016/j.rvsc.2021.03.019 |
| Popis: | Cranial cruciate ligament rupture (CCLR) is one of the most common orthopaedic disorders diagnosed in dogs yet the factors which influence postoperative clinical outcomes are poorly understood. Low vitamin D status has been linked to poorer clinical outcomes in human patients undergoing elective orthopaedic surgery. The aim of this study was to examine the relationship between pre-operative vitamin D status, as defined by serum 25 hydroxyvitamin D (25(OH)D) concentrations, and initial disease severity and clinical outcomes in dogs undergoing surgical treatment for a CCLR. Serum 25(OH)D concentrations were measured in 44 dogs with a CCLR on the day before surgery. C-reactive protein concentrations were measured at a median time of 1 day post-surgery and the patient's clinical and radiographic response to CCLR surgical treatment was assessed at a median timepoint of 60 days post-surgery. Serum 25(OH)D concentrations in dogs with a CCLR was not significantly different to a population of healthy dogs (median 74.1 nmol/L and 88.40 nmol/L, respectively). There was no significant correlation between pre-operative serum 25(OH)D concentrations and length of pre-diagnosis clinical signs, pre-operative lameness scores or day 1 post-operative CRP concentrations. Thirty nine of the 44 dogs were re-examined at a median 60 days post-surgery. There was no relationship between the day 60 lameness scores and pre-operative serum 25(OH)D concentrations. In summary, we discovered that the vitamin D status of dogs with a CCLR was not significantly lower than healthy dogs and pre-operative serum 25(OH)D concentrations were not correlated to either pre-surgical disease severity or post-operative clinical outcomes. |
| Databáze: | OpenAIRE |
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