Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
| Autor: | Sibylle M. Gomes, Anna Olivieri, L. Souto, Gabriela Huber, Alessandro Achilli, Bettina Zimmermann, Antonio Torroni, Francisco Corte-Real, Alexander W. Röck, Martin Bodner, Christina Strobl, Walther Parson |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
mtDNA haplogroup P
First settlers Male 0106 biological sciences Timor-Leste Lineage (evolution) Population genetics 01 natural sciences Haplogroup History Ancient Phylogeny Genetics 0303 health sciences education.field_of_study Geography Human migration Mitochondrial DNA East Timor (Timor-Leste) Female Research Article Biotechnology haplogroup Human Migration Molecular Sequence Data Population Biology DNA Mitochondrial 010603 evolutionary biology Forensic mtDNA analysis 03 medical and health sciences Asian People Next generation sequencing Human settlement Humans East Asia education 030304 developmental biology Chromosomes Human Y business.industry Australia population genetics Ion Torrent PGM Haplotypes Island Southeast Asia Evolutionary biology Human mtDNA haplogroup population genetics Human mtDNA business |
| Zdroj: | BMC Genomics |
| Popis: | Background Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. Results In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations |
| Databáze: | OpenAIRE |
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