Association analysis between the C-1291G polymorphism in the promoter region of the adrenergic α2A receptor gene and polydipsia in schizophrenia
| Autor: | Wakana Yamaguchi, Rudi Hwang, Osamu Ohmori, Takahiro Shinkai, Yoshiaki Inoue, Yuko Fukunaka, Hsin-I Chen, Kenji Yamada, Jun Nakamura, Shinichi Sakata, Kensuke Utsunomiya |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Genotype DNA Mutational Analysis Drinking Behavior Adrenergic Clonidine Association Gene Frequency Receptors Adrenergic alpha-2 Internal medicine mental disorders medicine Humans Promoter Regions Genetic Allele frequency Biological Psychiatry Genetic association Pharmacology Chi-Square Distribution Polymorphism Genetic Middle Aged medicine.disease Mianserin Logistic Models Endocrinology Schizophrenia Female medicine.symptom Psychology Adrenergic alpha-Agonists Polydipsia medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 33:499-502 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2009.01.012 |
| Popis: | Several lines of studies have shown the existence of an important inhibitory mechanism for the control of water intake involving adrenergic alpha2A receptors (ADRA2A). A human study using patients with schizophrenia demonstrated an exacerbation of polydipsia by the administration of clonidine, an ADRA2A-agonist, and a relief of polydipsia by mianserin, an ADRA2A-antagonist, suggesting the involvement of the central adrenergic system in the drinking behavior of patients with schizophrenia. Based on these findings we examined a possible association between the C-1291G polymorphism in the promoter region of the ADRA2A gene and polydipsia in schizophrenia using a Japanese case-control sample. Our sample includes 348 patients with schizophrenia (DSM-IV) (84 with polydipsia and 264 without polydipsia). No significant association between the ADRA2A C-1291G polymorphism and polydipsia was found. Our result suggests that the ADRA2A C-1291G polymorphism may not confer susceptibility to polydipsia in schizophrenia in our sample. Further studies with larger samples are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect