Suppression of myocardial glucose metabolism in FDG PET/CT: impact of dose variation in heparin bolus pre-administration

Autor:	Asbjørn M. Scholtens, Jan Paul Esser, N. L. van der Sluis, Hein J. Verberne, G. K. Lammers, A. M. van den Berk, Marnix G.E.H. Lam, J. M. H. De Klerk
Přispěvatelé:	Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences
Rok vydání:	2020
Předmět:	Blood pool Glucose uptake Low carbohydrate diet Carbohydrate metabolism 030218 nuclear medicine & medical imaging Cardiac glucose metabolism 03 medical and health sciences 0302 clinical medicine Bolus (medicine) Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Retrospective Studies Inflammation Fluorodeoxyglucose Heparin business.industry Myocardium Reproducibility of Results General Medicine FDG PET/CT Glucose 030220 oncology & carcinogenesis Ct technique Fdg pet ct Radiopharmaceuticals Infection Nuclear medicine business medicine.drug
Zdroj:	European journal of nuclear medicine and molecular imaging, 47(11), 2698-2702. Springer Verlag
ISSN:	1619-7089 1619-7070
Popis:	Introduction: Adequate suppression of physiologic myocardial glucose uptake is important to ensure the interpretability and diagnostic reliability of [18F]fluorodeoxyglucose (FDG) PET/CT studies performed in the context of cardiac inflammation and infection. This study describes our experience with 4 preparatory protocols used in our institution. Methods: FDG PET/CT scans were performed according to 4 preparatory protocols (716 scans total), i.e. 6-h fast (group 1), low-carbohydrate diet plus 12-h fast (group 2), low-carbohydrate diet plus 12-h fast plus intravenous heparin pre-administration (15 IU/kg) (group 3), and low-carbohydrate diet plus 12-h fast plus intravenous heparin pre-administration (50 IU/kg) (group 4). Consecutive scans were retrospectively included from time frames during which the particular protocol was used. FDG uptake in normal myocardium was scored on a scale ranging from 0 (uptake less than that in the left ventricular blood pool) to 4 (diffuse uptake greater than that in the liver). Complete suppression was defined as uptake less than or equal to the blood pool (scores 0–1). Results: Complete suppression was accomplished in 27% in group 1, 68% in group 2, 69% in group 3 and 81% in group 4. Complete suppression was significantly lower in group 1 compared with all other groups (P < 0.0001 for all comparisons) and significantly higher in group 4 compared with group 2 (P = 0.005) and group 3 (P = 0.007). Groups 2 and 3 did not differ significantly (P = 0.92). Conclusion: A total of 50 IU/kg single-dose heparin administration before FDG PET/CT in addition to a low-carbohydrate diet and prolonged fast significantly outperformed protocols with no or lower dose (15 IU/kg) heparin in completely suppressing myocardial glucose metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3877b12e01080f2e6a7de568dcb7af86 https://doi.org/10.1007/s00259-020-04713-1 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.