The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity

Autor: Undral Munkhsaikhan, Youngin Kwon, Amal M. Sahyoun, Karima Ait‐Aissa, Adam Kassan, Modar Kassan
Rok vydání: 2022
Předmět:
Zdroj: Obesity (Silver Spring)
ISSN: 1930-739X
1930-7381
DOI: 10.1002/oby.23389
Popis: OBJECTIVES: In this study, we investigate the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity. METHODS: Eight-week-old C57BL/6 mice were fed with high fat diet (HFD) for 12 weeks in the presence and absence of lomitapide. Lomitapide was administered by gavage (1mg/Kg/Day) during the last 2 weeks of HFD feeding. Bodyweight, blood glucose, body composition, and lipid profile were determined. Vascular function and endothelial function markers were studied in the aorta and mesenteric resistance arteries (MRA). KEY RESULTS: Lomitapide treatment reduced the body weight in mice with obesity. Blood glucose, % of fat mass, total cholesterol, and LDL levels were significantly reduced, and the % of lean mass was significantly increased after lomitapide treatment. Aortic and mesenteric arteries vascular response to sodium nitroprusside (SNP) was similar among groups. However, the vascular response to acetylcholine (Ach) was improved in the treated group. This was associated with decreased levels of vascular endoplasmic reticulum (ER) stress, inflammation, and oxidative stress. CONCLUSIONS: Treatment with lomitapide attenuated the increase in body weight in mice with obesity and restored the lipid profile and vascular function. These effects were accompanied by a decrease in inflammation and oxidative stress.
Databáze: OpenAIRE
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