Clinical Significance of Hepatitis C Virus Genotypes

Autor:	N N, Zein
Rok vydání:	2000
Předmět:	Microbiology (medical) Genotype General Immunology and Microbiology Epidemiology Public Health Environmental and Occupational Health virus diseases Genome Viral Hepacivirus Antiviral Agents Hepatitis C Article digestive system diseases Infectious Diseases Disease Progression Humans Interferons
Zdroj:	Clinical Microbiology Reviews. 13:223-235
ISSN:	1098-6618 0893-8512
DOI:	10.1128/cmr.13.2.223
Popis:	SUMMARY On the basis of phylogenetic analysis of nucleotide sequences, multiple genotypes and subtypes of hepatitis C virus (HCV) have been identified. Characterization of these genetic groups is likely to facilitate and contribute to the development of an effective vaccine against infection with HCV. Differences among HCV genotypes in geographic distributions have provided investigators with an epidemiologic marker that can be used to trace the source of HCV infection in a given population. HCV genotype 1 may represent a more aggressive strain and one that is less likely to respond to interferon treatment than HCV genotype 2 or 3. However, these observations require confirmation before HCV genotyping can be used in clinical settings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387311f6cdde6d29d471cabb69fe7a86 https://doi.org/10.1128/cmr.13.2.223 Zobrazit plný text záznamu