Investigation of associations between ten polymorphisms and the risk of coronary artery disease in Southern Han Chinese
| Autor: | Bin Luo, Jianding Cheng, Dan Wang, Zhao-Hui Li, Chao Liu, Guo-Li Lv, Li Quan, Zhong-Yi Yang, Shui-Ping Liu, Long-Yun Peng, Xiao-Shan Liu, Jian Zhao, Er-Wen Huang, Qiuping Wu, Shuangbo Tang, He Shi, Jin-Xiang Zheng, Xiao-Hong Tan, Xue-Mei Li |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Risk China Genotype Genome-wide association study Coronary Artery Disease Biology Polymorphism Single Nucleotide 03 medical and health sciences Asian People Gene Frequency Genetics Odds Ratio Humans Genetic Predisposition to Disease cardiovascular diseases Allele frequency Genotyping Genetics (clinical) Alleles Genetic Association Studies Genetic association Case-control study Odds ratio 030104 developmental biology Genetic epidemiology Case-Control Studies Pharmacogenetics Genome-Wide Association Study |
| Zdroj: | Journal of human genetics. 61(5) |
| ISSN: | 1435-232X |
| Popis: | A large-scale meta-analysis of 14 genome-wide association studies has identified and replicated a series of susceptibility polymorphisms for coronary artery disease (CAD) in European ancestry populations, but evidences for the associations of these loci with CAD in other ethnicities remain lacking. Herein we investigated the associations between ten (rs579459, rs12413409, rs964184, rs4773144, rs2895811, rs3825807, rs216172, rs12936587, rs46522 and rs3798220) of these loci and CAD in Southern Han Chinese (CHS). Genotyping was performed in 1716 CAD patients and 1572 controls using mass spectrography. Both allelic and genotypic associations of rs964184, rs2895811 and rs3798220 with CAD were significant, regardless of adjustment for covariates of gender, age, hypertension, type 2 diabetes, blood lipid profiles and smoking. Significant association of rs12413409 was initially not observed, but after the adjustment for the covariates, both allelic and genotypic associations were identified as significant. Neither allelic nor genotypic association of the other six polymorphisms with CAD was significant regardless of the adjustment. Our results indicated that four loci of the total 10 were associated with CAD in CHS. Therefore, some of the CAD-related loci in European ancestry populations are indeed susceptibility loci for the risk of CAD in Han Chinese. |
| Databáze: | OpenAIRE |
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