Serum β-endorphin levels are associated with addiction to suicidal behavior: A pilot study
| Autor: | Encarnación Donoso-Navarro, Teresa Ponte-López, Elena Hernandez-Alvarez, Igor Horrillo, Hilario Blasco-Fontecilla, Antonio J. Sánchez-López, J. Javier Meana, Ana Royuela, Silvia Rosado-Garcia, María Gil-Ligero, Javier Herranz-Herrer, Elena Gil-Benito |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Behavioral addiction media_common.quotation_subject Pilot Projects Suicide Attempted Neglect Suicidal Ideation 03 medical and health sciences Young Adult 0302 clinical medicine mental disorders medicine Humans Pharmacology (medical) Psychological abuse Biological Psychiatry media_common Pharmacology Substance dependence business.industry Addiction Adult Survivors of Child Abuse beta-Endorphin Middle Aged medicine.disease 030227 psychiatry Behavior Addictive Psychiatry and Mental health Neurology Schizophrenia Biomarker (medicine) Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Biomarkers Clinical psychology Buprenorphine medicine.drug |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 40 |
| ISSN: | 1873-7862 |
| Popis: | The literature provides partial support for the hypothesis that some suicide attempters develop a behavioral addiction to suicidal behavior (SB). We hypothesized that major suicide repeaters (MR) (≥5 lifetime suicide attempts) are addicted to suicide attempts as measured by modified DSM-IV criteria for substance dependence. In this cross-sectional study with 13 psychiatric controls (PC), 55 non-major suicide attempters (NMR), and 9 MR we found that MR are characterized by emotional abuse and neglect, as well as higher scores on the Personality and Life Event scale (short version). The levels of 8 AM serum ACTH, cortisol and β-endorphin were elevated in all three groups. Serum β-endorphin (pg/mL) was particularly high in PC diagnosed with schizophrenia 220.34 (±56.30). The level of 8 AM serum β-endorphin rose with increased numbers of criteria met for addiction to SB from 130.31 (±88.16) (≥ 3 criteria met for addiction to SB) to 174.84 (±114.93) (≥ 6 criteria met for addiction to SB) whereas serum ACTH and cortisol did not change. SB addicts (≥ 6 criteria) displayed higher serum β-endorphin concentrations than non-addicts (174.84 ± 114.93 vs. 116.93 ± 61.70, FET p = 0.09). The present study brings some support to the addictive hypothesis of SB. Our results delineate β-endorphin as a promising biomarker of SB addiction, and offer a good basis for future studies that test whether buprenorphine can be used to prevent repetitive suicide attempts, non-suicidal-self-injury (NSSI), and the development of an addiction to SB. |
| Databáze: | OpenAIRE |
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