IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway

Autor: Shuai-xing Wang, Ye-nan Feng, Shan Feng, Ji-min Wu, Mi Zhang, Wen-li Xu, You-yi Zhang, Hai-bo Zhu, Han Xiao, Er-dan Dong
Rok vydání: 2022
Předmět:
Zdroj: Acta Pharmacologica Sinica. 43:2542-2549
ISSN: 1745-7254
1671-4083
Popis: Upon chronic stress, β-adrenergic receptor activation induces cardiac fibrosis and leads to heart failure. The small molecule compound IMM-H007 has demonstrated protective effects in cardiovascular diseases via activation of AMP-activated protein kinase (AMPK). This study aimed to investigate IMM-H007 effects on cardiac fibrosis induced by β-adrenergic receptor activation. Because adenosine analogs also exert AMPK-independent effects, we assessed AMPK-dependent and -independent IMM-H007 effects in murine models of cardiac fibrosis. Continual subcutaneous injection of isoprenaline for 7 days caused cardiac fibrosis and cardiac dysfunction in mice in vivo. IMM-H007 attenuated isoprenaline-induced cardiac fibrosis, diastolic dysfunction, α-smooth muscle actin expression, and collagen I deposition in both wild-type and AMPKα2
Databáze: OpenAIRE
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