Plastic Rewiring of Sef1 Transcriptional Networks and the Potential of Nonfunctional Transcription Factor Binding in Facilitating Adaptive Evolution
| Autor: | Tzu-Chiao Lu, Jun-Yi Leu, Chia-Wei Liao, Ahmed A. A. Amine, Yu-Ting Jhou, Po-Chen Hsu, Po-Hsiang Hung |
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| Rok vydání: | 2021 |
| Předmět: |
Lachancea kluyveri
Computational biology AcademicSubjects/SCI01180 03 medical and health sciences TCA cycle regulation 0302 clinical medicine transcriptional network evolution Yeasts Candida albicans Genetics Transcriptional regulation Gene Regulatory Networks nonfunctional transcription factor binding Molecular Biology Gene Transcription factor Discoveries Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences transcriptional rewiring biology AcademicSubjects/SCI01130 biology.organism_classification Phenotype Yeast Plastics phenotypic diversity 030217 neurology & neurosurgery Function (biology) Transcription Factors |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 0737-4038 |
| DOI: | 10.1093/molbev/msab192 |
| Popis: | Prior and extensive plastic rewiring of a transcriptional network, followed by a functional switch of the conserved transcriptional regulator, can shape the evolution of a new network with diverged functions. The presence of three distinct iron regulatory systems in fungi that use orthologous transcriptional regulators suggests that these systems evolved in that manner. Orthologs of the transcriptional activator Sef1 are believed to be central to how iron regulatory systems developed in fungi, involving gene gain, plastic network rewiring, and switches in regulatory function. We show that, in the protoploid yeast Lachancea kluyveri, plastic rewiring of the L. kluyveri Sef1 (Lk-Sef1) network, together with a functional switch, enabled Lk-Sef1 to regulate TCA cycle genes, unlike Candida albicans Sef1 that mainly regulates iron-uptake genes. Moreover, we observed pervasive nonfunctional binding of Sef1 to its target genes. Enhancing Lk-Sef1 activity resuscitated the corresponding transcriptional network, providing immediate adaptive benefits in changing environments. Our study not only sheds light on the evolution of Sef1-centered transcriptional networks but also shows the adaptive potential of nonfunctional transcription factor binding for evolving phenotypic novelty and diversity. |
| Databáze: | OpenAIRE |
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